Jamie Davies twice had Llanfair in the lead at Porthmadog but late goals saw the Mount Field side go down 4-2 in the Huws Gray Alliance.
Guilsfield suffered a surprise setback when they went down 5-3 at Denbigh despite goals from Jake Cooke and Adam Jenkins (2).
Match of the day in the Central Wales Cup saw Berriew beaten 3-2 at Llanidloes to end a four month unbeaten run. Dave Roberts and Steff Rogers notched for Berriew but Llani won through Gareth Owen, George Clarke and an own goal.
Cup holders Carno are also through after a convincing 8-2 win over Llanfyllin.
Huws Gray Alliance
Caersws 1 Buckley 0
Denbigh 5 Guilsfield 3
Porthmadog 4 Llanfair 2
Central Wales Cup
Carno 8 Llanfyllin 2
Kerry 0 Llanrhaeadr 2
Llanidloes 3 Berriew 2
Llansantffraid 4 Newbridge 1
Llanymynech P Aberaeron P
Trewern 1 Churchstoke 3
Tywyn/Bryncrug 3 Dyffryn Banw 0
Spar Mid Wales League
Division 2
Four Crosses 4 Penybont 3